The ultrasonic sonication transducer based on the principle of Langevin transducer is a common liquid process device. It uses the mechanical oscillation and cavitation of high-frequency ultrasound in the liquid to mix, stir, disperse the solution and suspension. Common ultrasonic sonicator for ultrasonic cell lysis and ultrasonic cell disruption is based on this principle. However, the power of the above general ultrasonic sonicator is relatively large, and the ultrasonic probe needs to contact the liquid. In some applications of in vitro diagnosis, biological samples usually need to be homogenized and lysis, and most of the samples are only small doses in milliliter or even microliter scale. Moreover, if the ultrasonic sonicator probe contacts the sample, it may pollute the sample. Therefore, the traditional ultrasonic sonicator is not suitable for these applications in IVD.
Siansonic's unique ‘dry non-invasive’ ultrasonic sonication transducer can transfer high-frequency ultrasonic energy into the sample container only by contacting the outer wall of the sample container without applying any coupling agent to carry out ultrasonic sonication process on the sample. Moreover, the small ultrasonic sonicator transducer can be used for homogenizing and lysis the small dose of sample solution with low power. Siansonic's ultrasonic sonication transducer have been used for applications of molecular diagnosis for nearly 20 years, and been used as the long-term key component by many companies in this industry, such as Cepheid and Biocartis. After the outbreak of COVID-19 in 2019, the virus detection technology based on PCR (polymerase chain reaction) played an important role in the epidemic control. The non-invasive sample sonication transducer is a product specially designed and developed by Siansonic for rapid PCR technology.